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In previous studies even a small transient exposure of cells to stress agents, such as UV, H 2 O 2 , or oxidant chemicals, causes substantial LPO, leading to a significant rise in 4HNE, which is considered to be one of the most abundant cytotoxic aldehydes (Yang et al., 2001
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In addition, a weak intracellular distribution was observed throughout the human epidermis and especially in the stratum corneum ( Chronic exposure of the skin to sunlight promotes premature aging, reduces its immunological response to environmental antigens and is the main risk factor in the development of a variety of precancerous and malignant skin neoplasms due to the uncontrolled growth of keratinocytes and melanocytes ( Skin tumors develop mainly in areas most exposed to the sun: face, ears, neck and scalp ( ex vivo human full-thickness skin exposed to UVR in a dose- (0, 100, 300 mJ/cm 2 ) and time- (0, 24, 48 h post-UVR) dependent manner